Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

January 15, 2015
A011202
Breast Cancer
Oh-Hoon Kwon, MD

Edward Cancer Center - Naperville
Edward Cancer Center - Plainfield
Nancy Knowles Cancer Center - Elmhurst

This randomized phase III trial studies lymph node dissection and radiation therapy to see how well it works compared to radiation therapy alone in treating patients with breast cancer previously treated with chemotherapy and surgery. Lymph node dissection may remove cancer cells that have spread to nearby lymph nodes in patients with breast cancer. Radiation therapy uses high-energy x rays or protons to kill tumor cells. It is not yet known if radiation therapy works better alone or with lymph node dissection in treating patients with breast cancer previously treated with chemotherapy and surgery.

Sponsor: Alliance for Clinical Trials in Oncology

https://clinicaltrials.gov/ct2/show/NCT01901094

  • Clinical stage T1-3 N1 M0 breast cancer at diagnosis 
  • No other malignancy within 5 years (except basal cell or squamous cell carcinoma or carcinoma in situ of the cervix)
  • No more than 8 weeks of endocrine therapy prior to the start of neoadjuvant chemotherapy
  • Completed all neoadjuvant chemotherapy prior to surgery; at least 4 cycles must include an anthracycline and/or taxane-based regimen without progression
  • No neoadjuvant radiation therapy
  • No prior history of breast cancer and no current invasive breast cancer in the other breast; benign breast disease; LCIS or DCIS is allowed

5-6 years

Accepting Participants
Interventional
III
Sofia Mikac, BSN
630-646-6073
630-646-6074
630-646-6072